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    Edward B Mougey, PhD

    Research Scientist

    911ÖÆÆ·³§Â黨, Jacksonville 807 Children's Way Jacksonville, FL 32207

    Biography

    Edward Mougey, Ph.D. is a member of the Center for Pharmacogenomics and Translational Research at 911ÖÆÆ·³§Â黨's Specialty Care in Jacksonville, Florida. He received his Ph.D. in chemistry from the University of Delaware and went on to complete several Postdoctoral Fellowships at the Johns Hopkins School of Medicine. Dr. Mougey is currently working with Jim Franciosi, MD, to develop precision medicine algorithms for application to gastrointestinal disorders. Trained as a chemist, he has extensive experience in pharmacogenetics and pharmacogenomics and has published on the pharmacogenetics of asthma controller therapy. Currently, Dr. Mougey is focused on improving response rates to proton pump inhibitor (PPI) therapy for eosinophilic esophagitis (EoE) and has identified genetic variants in the genes for STAT6 and CYP2C19 that interact and predispose children to fail PPI therapy for EoE.

    Education

    • PhD - University of Delaware, Department of Chemistry, 1988
    • Postdoctoral Fellow - Johns Hopkins University School of Medicine, Department of Biological Chemistry, 1996
    • Bachelor of Science - University of Maryland, College Park, Department of Chemistry, 1982

    • Eosinophilic Esophagitis
    • Pharmacogenomics
    • Precision Medicine

    • Comparative Effectiveness of Intravenous Azithromycin Versus Erythromycin Stimulating Antroduodenal Motility in Children.; Journal of pediatric gastroenterology and nutrition; (2022).

    • Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis: History, Mechanisms, Efficacy, and Future Directions.; Journal of asthma and allergy; (2022).

    • Telehealth for Pediatric Gastroenterology Care Now; JPGN Reports; (2022).

    • STAT6 Variants Associate With Relapse of Eosinophilic Esophagitis in Patients Receiving Long-term Proton Pump Inhibitor Therapy; Clinical Gastroenterology and Hepatology; (2021).

    • Pharmacogenomics fail to explain proton pump inhibitor refractory esophagitis in pediatric esophageal atresia; Neurogastroenterology and Motility; (2021).

    • Novel Implementation of Genotype-Guided Proton Pump Inhibitor Medication Therapy in Children: A Pilot, Randomized, Multisite Pragmatic Trial; Clinical and Translational Science; (2019).

    • Genotype tailored treatment of mild symptomatic acid reflux in children with uncontrolled asthma (GenARA): Rationale and methods; Contemporary Clinical Trials; (2019).

    • Fish oil supplementation in overweight/obese patients with uncontrolled asthma a randomized trial; Annals of the American Thoracic Society; (2019).

    • CYP2C19 and STAT6 Variants Influence the Outcome of Proton Pump Inhibitor Therapy in Pediatric Eosinophilic Esophagitis; Journal of Pediatric Gastroenterology and Nutrition; (2019).

    • Association Between CYP2C19*17 Alleles and pH Probe Testing Outcomes in Children With Symptomatic Gastroesophageal Reflux; Journal of Clinical Pharmacology; (2018).

    • Association between CYP2C19 extensive metabolizer phenotype and childhood anti-reflux surgery following failed proton pump inhibitor medication treatment; European Journal of Pediatrics; (2018).

    • Free 25(OH)D concentrations are associated with atopy and lung function in children with asthma; Annals of Allergy, Asthma and Immunology; (2017).

    • The Duffy antigen receptor for chemokines regulates asthma pathophysiology; Clinical and Experimental Allergy; (2017).

    • Serum folate concentrations, asthma, atopy, and asthma control in Peruvian children; Respiratory Medicine; (2017).

    • Association between serum 25-hydroxy Vitamin D levels and blood pressure among adolescents in two resource-limited settings in Peru; American Journal of Hypertension; (2015).

    • 25-hydroxy vitamin D levels are associated with childhood asthma in a population-based study in Peru; Clinical and Experimental Allergy; (2015).

    • Prevalence and risk factors for allergic rhinitis in two resource-limited settings in Peru with disparate degrees of urbanization; Clinical and Experimental Allergy; (2015).

    • Effect of a soy isoflavone supplement on lung function and clinical outcomes in patients with poorly controlled asthma: A randomized clinical trial; JAMA - Journal of the American Medical Association; (2015).

    • Lansoprazole is associated with worsening asthma control in children with the CYP2C19 poor metabolizer phenotype; Annals of the American Thoracic Society; (2015).

    • ALOX5 Polymorphism associates with increased leukotriene production and reduced lung function and asthma control in children with poorly controlled asthma; Clinical and Experimental Allergy; (2013).

    • Methacholine PC<inf>20</inf> in African Americans and whites with asthma with homozygous genotypes at ADRB2 codon 16; Pulmonary Pharmacology and Therapeutics; (2013).

    • Nutrigenetic response to omega-3 fatty acids in obese asthmatics (NOOA): Rationale and methods; Contemporary Clinical Trials; (2013).

    • Biologic mechanisms of environmental tobacco smoke in children with poorly controlled asthma: Results from a multicenter clinical trial; Journal of Allergy and Clinical Immunology: In Practice; (2013).

    • Association of CYP2C19 polymorphisms and lansoprazole-associated respiratory adverse effects in children; Journal of Pediatrics; (2013).

    • Pharmacogenetics of asthma controller treatment; Pharmacogenomics Journal; (2013).

    • Effect of citrus juice and SLCO2B1 genotype on the pharmacokinetics of montelukast; Journal of Clinical Pharmacology; (2011).

    • Absorption of montelukast is transporter mediated: A common variant of OATP2B1 is associated with reduced plasma concentrations and poor response; Pharmacogenetics and Genomics; (2009).

    • Oxandrolone enhances skeletal muscle myosin synthesis and alters global gene expression profile in Duchenne muscular dystrophy; American Journal of Physiology - Endocrinology and Metabolism; (2006).

    • Mitochondrial ribosomal proteins: Candidate genes for mitochondrial disease; Genetics in Medicine; (2004).

    • Growth factor regulation of human growth plate chondrocyte proliferation in vitro; Biochemical and Biophysical Research Communications; (2004).

    • Using real-time, quantitative pcr for rapid genotyping of the steroid 21-hydroxylase gene in a north florida population; Journal of Clinical Endocrinology and Metabolism; (2002).

    • Determination of human beta(2)-adrenoceptor haplotypes by denaturation selective amplification and subtractive genotyping; American journal of pharmacogenomics : genomics-related research in drug development and clinical practice; (2001).

    • Mammalian mitochondrial ribosomal proteins (4): Amino acid sequencing, characterization, and identification of corresponding gene sequences; Journal of Biological Chemistry; (2000).

    • Heart-specific splice-variant of a human mitochondrial ribosomal protein (mRNA processing; tissue specific splicing); Gene; (2000).

    • Mammalian mitochondrial ribosomal proteins (2). Amino acid sequencing, characterization, and identification of corresponding gene sequences; Journal of Biological Chemistry; (1999).

    • Expression of the components of the insulin-like growth factor axis across the growth-plate; Molecular and Cellular Endocrinology; (1999).

    • Metazoan rDNA enhancer acts by making more genes transcriptionally active; Journal of Cell Biology; (1996).

    • Virtually the entire Xenopus laevis rDNA multikilobase intergenic spacer serves to stimulate polymerase I transcription; Journal of Biological Chemistry; (1996).

    • The terminal balls characteristic of eukaryotic rRNA transcription units in chromatin spreads are rRNA processing complexes; Genes and Development; (1993).

    • A U3 small nuclear ribonucleoprotein-requiring processing event in the 5′ external transcribed spacer of Xenopus precursor rRNA; Molecular and Cellular Biology; (1993).

    • Wheat Germ and Yeast RNA Polymerase II: Photoaffinity Labeling by 4-Thiouracil 5′-Monophosphate Positioned Uniquely at the 3′ End of an Enzyme-Bound [<sup>32</sup>P]-Containing Transcript; Biochemistry; (1993).

    • Expression of mouse and frog rRNA genes: transcription and processing; Molecular and Cellular Biochemistry; (1991).

    • News from the nucleolus: rRNA gene expression; Trends in Biochemical Sciences; (1991).

    • The Xenopus ribosomal DNA 60- and 81-base-pair repeats are position-dependent enhancers that function at the establishment of the preinitiation complex: analysis in vivo and in an enhancer-responsive in vitro system; Molecular and Cellular Biology; (1989).

    • Formation and characterization of precise eucaryotic transcription complexes using a semisynthetic DNA template and specific oligoribonucleotide primers; Analytical Biochemistry; (1988).